Skin: Causes mild skin irritation. 2. Slightly hazardous in case of skin contact (irritant, permeator), of Details of dossier compliance checks and testing proposal evaluation. More information about CAS and the CAS registry can be found here. Eliminate Any Ignition Until The Area Is Determinded To Be Free From Explosion Or Fire Hazards. 66/2010/EC, L 27/1, 30 Jan 2010 (T. 3 of Anx VI to CLP; Candidate List of SVHCs), EU. food packaging and storage, toys, mobile phones). This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. Fumaric acid for synthesis. Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and of substances in closed systems with minimal release. According to the annexes to the directive, storage areas and containers containing chemical substances or mixtures that are classified as hazardous according to the CLP Regulation (1272/2008/EC) must be marked and/or labeled. : 203-743-0 Molecular Weight: 116.07 Chemical Formula: HOOCCH=CHCOOH . Safety Data Sheet (Fumaric Acid) DATE PREPARED: 12/10/2015 Page 2 of 7 Section 3. REACH registered substance data was upgraded on 9th November. This section provides links to the list of precautions (precautionary statements) and to the guidance on safe use, if they have been provided in REACH registration dossiers. MALEIC ACID is a colorless to white crystalline solid. : HY-W015883 CAS No. Fumaric acid None identified 2. Product identifier Product name Fumaric acid Product number FF23617 CAS number 110-17-8 EC number 203-743-0 1.2. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). Hazards Identification. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Examples include recommended measures on fire-fighting, transport and recycling and disposal. Keep Fumaric Acid in a tightly closed container, stored in a cool, dry, ventilated area. 0000049695 00000 n Fumaric Acid Trans-butenedioic Acid, trans-1,2-Ethylenedicarboxylic acid 2-Butenedioic acid Allomaleic acid Boletic acid Donitic acid Lichenic acid Solid, White Crystalline. trailer 7.1. HAZARDS IDENTIFICATION Hazards Not Otherwise Classified: No information available Signal Word: WARNING OSHA Classification: Hazard Category: Hazard Statement: Eye Damage/Irritation 2A Causes serious eye irritation. Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. Isolate from incompatible substances. 0000048843 00000 n %%EOF SAFETY DATA SHEET: FUMARIC ACID FUMARIC ACID F765.32 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 HO2CCH:CHCO2H 116.07 While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. Workplace Signage: Annexes I and III, Directive 92/58/EEC, last amended by Directive 2014/27/EU, 5 March 2014, Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Plastic Materials and Articles Regulation, Safety and/or Health Signs at Work Directive, EC Inventory, Pre-Registration process, CAD - Chemical Agents Directive, Art. This substance is used for the manufacture of: chemicals. Product Name: FUMARIC ACID Revision Date: 03.06.2019 Page 3 of 6 5. They react in this way with all bases, both organic (for example, the amines) and inorganic. This is unique source of information on the chemicals manufactured and imported in Europe. Fumaric Acid | Structure, Uses, Hazards, & Properties | - Genuine chemistry - The ultimate resource for Chemistry. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. * Breathing Fumaric Acid can irritate the nose and throat causing coughing and wheezing. Fumaric acid-1,4-13 C 2,2,3-d 2 2 Product Results | Match Criteria: Product Name It covers their hazardous properties, classification and labelling, and information on how to use them safely. When heated to decomposition it emits irritating fumes and acrid smoke [Lewis, 3rd ed., 1993, p. 790]. Maleic anhydride rapidly forms maleic acid when in contact with water. There's a medical application for … Identification::: Fumaric Acid SAFETY DATA SHEET Product code:Not available. HAZARDS IDENTIFICATION 2.1 GHS classification PHYSICAL HAZARDS Not classified HEALTH HAZARDS Not classified ENVIRONMENTAL HAZARDS Not classified 2.2 GHS label elements, including precautionary statements Pictograms or hazard symbols None xref SAFETY DATA SHEET Fumaric Acid Issued: 01/06/2015 Page 2 Signal Word: Warning Hazard Statements: H319 Causes serious eye irritation. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. It's important to remember that eating processed foods increases your risk of developing a range of chronic conditions, including cancers of the stomach and the bowel. It is soluble in alcohol, slightly soluble […] C&L Inventory . At sufficiently high doses the material may be nephrotoxic(i. e. Philip Lutze, in Distillation, 2014. It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). Fire Fighting Measures Explosive Hazard : This material may form flammable dust-air mixtures when finely divided. Ingestion: May cause irritation of the digestive tract. ... fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid . InfoCards are updated when new information is available. * Contact can irritate and burn the skin and eyes. startxref OTHER HAZARDS FIRE AND EXPLOSION HAZARD: May form combustible dust concentrations in air. Contact with skin: May cause skin irritation. 0000003207 00000 n Succinic, fumaric, and malic acid are four-carbon diacids that are produced via similar biochemical paths [7].These acids can be used as building blocks for the production of large commodity chemicals, such as 1,4-butanediol, tetra-hydrofuran, hydroxybutyrolacetone [7], or succinates [27,28]. e�� ��c㺼\\y1����M)�jAg�b-C'��m�-��V�� �B���=@��,�SHM7��"!�Sj> Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, EU. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, C&L Inventory, Pre-Registration process, CAD - Chemical Agents Directive, Art. 0000008487 00000 n Agricultural chemicals from maleic anhydride include pesticides, herbicides and growth regulators. Other Classifications: WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC). This substance has an industrial use resulting in manufacture of another substance (use of intermediates). Please upgrade your Internet Explorer to a newer version. Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. Fumaric acid uses include paper sizing, food acidulant and UPR manufacture. Fumaric acid According to Regulation (EC) No 1907/2006, Annex II, as amended. Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, of substances in closed systems with minimal release and in the production of articles. 0000001325 00000 n Hazardous Reactions None under normal processing. 0000005970 00000 n 2; H319 <= 100 % EC-No. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Y]����Uǃ[�nШ뾛%4Ne���]ֵ���?5��!��! P264 Wash hands thoroughly after handling. When information is available in all sources, the first two are displayed as a priority. : 110-17-8 EINICS EC-No. fumaric acid 110-17-8 > 99 Section 4 - FIRST AID MEASURES SWALLOWED If swallowed do NOT induce vomiting. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. In that case, the ATP (Adaptation to Technical Progress) number is displayed. A substance identified primarily by an EC or list number may be linked with more than one CAS number, or with CAS numbers that have been deleted. There is no data available. This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The molecular structure is based on structures generated from information available in ECHA’s databases. Means of Extinction : Water, carbon dioxide, dry chemicals, wear self-contained InfoCards are generated automatically based on the data available at the time of generation. S 37 Wear suitable gloves. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. Fumaric acid is a stable and harmless compound by contact with the skin or eyes. It is generally used in beverages and baking powders for which requirements are placed on purity. 0000003285 00000 n Pennsylvania RTK: Fumaric acid Massachusetts RTK: Fumaric acid TSCA 8(b) inventory: Fumaric acid CERCLA: Hazardous substances. Fumaric acid has been used as a food acidulant since 1946. 7. Though Fumaric Acid E297 is considered safe, some are convinced it has potentially dangerous health effects. This information has not been reviewed or verified by ECHA, and may change without prior notice. 110-17-8 Fumaric acid 99% 203-743-0 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes. Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. Substances may have impurities and additives that lead to different classifications. There is no data available. Other Classifications: WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Gives off irritating or toxic fumes (or gases) in a fire. Product name : Fumaric acid Catalog No. The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. * Fumaric Acid may damage the kidneys. (USCG, 1999) FUMARIC ACID is a carboxylic acid. 0000006655 00000 n Chemsrc provides fumaric acid(CAS#:110-17-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Other: Consult professionals if Fumaric Acid need to be handled under some special conditions. 203-743-0 Index-No. Ingestion: No hazard expected in normal industrial use. Pennsylvania RTK: Fumaric acid Massachusetts RTK: Fumaric acid TSCA 8(b) inventory: Fumaric acid CERCLA: Hazardous substances. 0 However, substance notifications in the InfoCard are aggregated independently of the impurities and additives. 0000032684 00000 n 29 0 obj<> endobj Persistence and degradability FUMARIC ACID CRS(110-17-8) Biodegradation 98 12.3. 0000003770 00000 n This substance can be found in products with material based on: plastic (e.g. 7.2. Registration dossier . inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. 0000001188 00000 n 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Pre-Registration process, Other, CAD - Chemical Agents Directive, Art. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically generated for the InfoCard. Skin : Wash Thoroughly With Soap And Water. Other release to the environment of this substance is likely to occur from: indoor use (e.g. disodium tetraborate EC no. Its chemical formula is HO 2 CCH=CHCO 2 H. Maleic acid is the cis-isomer of butenedioic acid, whereas fumaric acid is the trans-isomer.It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. The hazard assessment of this substance is triggered by the effects observed in a chronic repeated dose toxicity study. 32 0 obj<>stream EU. Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. R 36/37/38 Irritating to eyes, respiratory system and skin. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. Prolonged contact with eyes or skin may cause irritation. Their reactions with bases, called "neutralizations", are accompanied by … : 682001: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP ... fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid. Contact with eyes: May cause eye irritation. it is recommended that all dust control equipment and material transport systems involved are engineered to prevent conditions contributing to dust explosions. 106301-Fumaric acid Version: 2 Revision date: 19/04/2016 Page 1 of 8 Print date: 19/04/2016 -Continued on next page.-SECTION 1: IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY/UNDERTAKING. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. What Is Fumaric Acid E297? Fumaric acid is prepared: (1) By boiling maleic acid with hydrochloric acid or sodium hydroxide. Guidance on safe use - recommendations by substance registrant on the proper use of the substance in various situations. When heated in sealed vessels with water at 150 - 170\u00b0C it forms DL-malic acid. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. GHS product identifier Other means of identification Product type Section 1. 0000000016 00000 n Fumaric acid is sometimes found in processed foods such as smoked meats. It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. 29 30 Special Hazards of Combustion Products: Irritating smoke containing maleic anhydride may form in fire. This site is not fully supported in Internet Explorer 7 (and earlier versions). FUMARIC ACID is a carboxylic acid. If vomiting occurs, lean patient forward or place … Other relevant information includes the following: To see the full list of notified classifications and to get more information on impurities and additives relevant to classification please consult the C&L Inventory. 170\U00B0C it forms DL-malic acid in that case, the victim should be allowed to in! 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